This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

Antiretroviral Therapy (ART) is an effective treatment for human immunodeficiency virus
(HIV) which has transformed the highly lethal disease, acquired immunodeficiency …

Transition-metal catalyzed carbosilylation of alkenes using carbon electrophiles and
silylmetal (-B,-Zn) reagents as the nucleophiles offers a powerful strategy for synthesizing …

Subunit-selective inhibition of N-methyl-d-aspartate receptors (NMDARs) is a promising
therapeutic strategy for several neurological disorders, including epilepsy, Alzheimer's and …

A series of new O-(substituted benzyl) phosphoramidate prodrugs of tenofovir for the
treatment of hepatitis B virus (HBV) infections have been designed and synthesized. An …

Cancers harboring homozygous deletion of the glycolytic enzyme enolase 1 (ENO1) are
selectively vulnerable to inhibition of the paralogous isoform, enolase 2 (ENO2). A previous …

Inherently limited by poor bioavailability, antiviral agent tenofovir (TFV) is administered to
people living with HIV in prodrug form. However, current prodrugs are prematurely …

Nucleoside-and nucleotide-based therapeutics are indispensable treatment options for
patients suffering from malignant and viral diseases. These agents are most commonly …

Metabolically labile prodrugs can experience stark differences in catabolism incurred by the
chosen route of administration. This is especially true for phosph (on) ate prodrugs, in which …

Integrating lipid conjugation strategies into the design of nucleoside monophosphate and
monophosphonate prodrugs is a well-established approach for discovering potential …