Immunological considerations for COVID-19 vaccine strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …
Potential intestinal infection and faecal–oral transmission of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than
200 countries and regions globally. SARS-CoV-2 is thought to spread mainly through …
200 countries and regions globally. SARS-CoV-2 is thought to spread mainly through …
Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity
BL Hartwell, MB Melo, P Xiao, AA Lemnios… - Science translational …, 2022 - science.org
To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry …
strategies are needed that elicit protection at mucosal portals of pathogen entry …
Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …
vaccinees, which can be especially dangerous in hospital settings while managing frail …
Reinfection with SARS-CoV-2: implications for vaccines
JI Cohen, PD Burbelo - Clinical Infectious Diseases, 2021 - academic.oup.com
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become
pandemic and the duration of protective immunity to the virus is unknown. Cases of persons …
pandemic and the duration of protective immunity to the virus is unknown. Cases of persons …
Progress and pitfalls in the quest for effective SARS-CoV-2 (COVID-19) vaccines
There are currently around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical
trials throughout the world. The various candidates employ a range of vaccine strategies …
trials throughout the world. The various candidates employ a range of vaccine strategies …
Optimize prime/boost vaccine strategies: trained immunity as a new player in the game
JL Palgen, Y Feraoun, G Dzangué-Tchoupou… - Frontiers in …, 2021 - frontiersin.org
Most vaccines require multiple doses to induce long-lasting protective immunity in a high
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
frequency of vaccines, and to ensure strong both individual and herd immunity. Repetitive …
Distinct features and functions of systemic and mucosal humoral immunity among SARS-CoV-2 convalescent individuals
SE Butler, AR Crowley, H Natarajan, S Xu… - Frontiers in …, 2021 - frontiersin.org
Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role
in the development of vaccines and antibody-based interventions. We report systemic and …
in the development of vaccines and antibody-based interventions. We report systemic and …
[HTML][HTML] COVID‐19: Current knowledge in clinical features, immunological responses, and vaccine development
R Singh, A Kang, X Luo, M Jeyanathan… - The FASEB …, 2021 - ncbi.nlm.nih.gov
The COVID‐19 pandemic has unfolded to be the most challenging global health crisis in a
century. In 11 months since its first emergence, according to WHO, the causative infectious …
century. In 11 months since its first emergence, according to WHO, the causative infectious …
Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model
PC Proud, D Tsitoura, RJ Watson, BY Chua… - …, 2021 - thelancet.com
Background The novel human coronavirus SARS-CoV-2 is a major ongoing global threat
with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in …
with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in …