Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro

B Prasad, D Grimm, SM Strauch, GS Erzinger… - International journal of …, 2020 - mdpi.com
All life forms have evolved under the constant force of gravity on Earth and developed ways
to counterbalance acceleration load. In space, shear forces, buoyance-driven convection …

The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

S Sawalha, S Abdallah, A Barham, H Badawi… - Nanoscale …, 2023 - pubs.rsc.org
Carbon nanodots, a family of carbon-based nanomaterials, have been synthesized through
different methods from various resources, affecting the properties of the resulting product …

Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro‐oncology

G Marfia, SE Navone, L Guarnaccia… - Journal of …, 2022 - Wiley Online Library
Abstract Space environment provides many challenges to pilots, astronauts, and space
scientists, which are constantly subjected to unique conditions, including microgravity …

[HTML][HTML] Gundelia tournefortii inhibits hepatocellular carcinoma progression by lowering gene expression of the cell cycle and hepatocyte proliferation in …

J Amer, A Salhab, N Jaradat, S Abdallah… - Biomedicine & …, 2022 - Elsevier
Gundelia (G.) tournefortii has antibacterial, anti-inflammatory, and hypolipemic effects. We
evaluated the anticancer effect of G. tournefortii in an hepatocellular carcinoma (HCC) …

Long-term simulation of microgravity induces changes in gene expression in breast cancer cells

J Sahana, JL Cortés-Sánchez, V Sandt… - International Journal of …, 2023 - mdpi.com
Microgravity changes the gene expression pattern in various cell types. This study focuses
on the breast cancer cell lines MCF-7 (less invasive) and MDA-MB-231 (triple-negative …

Cancer studies under space conditions: Finding answers abroad

JL Cortés-Sánchez, J Callant, M Krüger, J Sahana… - Biomedicines, 2021 - mdpi.com
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …

Alterations of growth and focal adhesion molecules in human breast cancer cells exposed to the random positioning machine

J Sahana, TJ Corydon, M Wehland… - Frontiers in cell and …, 2021 - frontiersin.org
In this study, we evaluated changes in focal adhesions (FAs) in two types of breast cancer
cell (BCC) lines (differentiated MCF-7 and the triple-negative MDA-MB-231 cell line) …

Dexamethasone selectively inhibits detachment of metastatic thyroid cancer cells during random positioning

D Melnik, JL Cortés-Sánchez, V Sandt, S Kahlert… - Cancers, 2023 - mdpi.com
Simple Summary Metastasis is the most dangerous feature of advanced cancers. In vitro
models of this process could help us to study and understand mechanisms that are not …