Challenges to the central nervous system during human spaceflight missions to Mars

GR Clément, RD Boyle, KA George… - Journal of …, 2020 - journals.physiology.org
Space travel presents a number of environmental challenges to the central nervous system,
including changes in gravitational acceleration that alter the terrestrial synergies between …

Space radiation biology for “Living in Space”

S Furukawa, A Nagamatsu, M Nenoi… - BioMed Research …, 2020 - Wiley Online Library
Space travel has advanced significantly over the last six decades with astronauts spending
up to 6 months at the International Space Station. Nonetheless, the living environment while …

Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology

JD Boice, B Quinn, I Al-Nabulsi, A Ansari… - The Million Person …, 2024 - taylorfrancis.com
Background: Epidemiologic studies of radiation-exposed populations form the basis for
human safety standards. They also help shape public health policy and evidence-based …

The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures

K Krukowski, K Grue, MK Becker, E Elizarraras… - Science …, 2021 - science.org
In the coming decade, astronauts will travel back to the moon in preparation for future Mars
missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle for deep space …

Quantification of radiation-induced DNA double strand break repair foci to evaluate and predict biological responses to ionizing radiation

S Penninckx, E Pariset, E Cekanaviciute… - NAR …, 2021 - academic.oup.com
Radiation-induced foci (RIF) are nuclear puncta visualized by immunostaining of proteins
that regulate DNA double-strand break (DSB) repair after exposure to ionizing radiation. RIF …

Understanding the effects of deep space radiation on nervous system: the role of genetically tractable experimental models

G Onorato, E Di Schiavi, F Di Cunto - Frontiers in Physics, 2020 - frontiersin.org
Space agencies are working to establish a permanent human presence on the moon and to
reach Mars within the next few decades. In these missions, astronaut crew members will be …

[HTML][HTML] The neurology of space flight; How does space flight effect the human nervous system?

U Gupta, S Baig, A Majid, SM Bell - Life Sciences in Space Research, 2023 - Elsevier
Abstract Rationale and Hypothesis Advancements in technology, human adaptability, and
funding have increased space exploration and in turn commercial spaceflight. Corporations …

The influence of physiological and pathological perturbations on blood-brain barrier function

N Zhao, TD Chung, Z Guo, JJ Jamieson… - Frontiers in …, 2023 - frontiersin.org
The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …

Progressive increase in the complexity and translatability of rodent testing to assess space-radiation induced cognitive impairment

RA Britten, LL Wellman, LD Sanford - Neuroscience & Biobehavioral …, 2021 - Elsevier
Ground-based rodent models have established that space radiation doses (approximately
those that astronauts will be exposed to on a mission to Mars) significantly impair …