Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches

M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …

[HTML][HTML] Mechanisms of resistance in castration-resistant prostate cancer (CRPC)

T Chandrasekar, JC Yang, AC Gao… - … andrology and urology, 2015 - ncbi.nlm.nih.gov
Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Apigenin: A dietary flavonoid with diverse anticancer properties

J Madunić, IV Madunić, G Gajski, J Popić… - Cancer letters, 2018 - Elsevier
Apigenin is a natural flavonoid found in several dietary plant foods such as vegetables and
fruits. A large number of studies conducted over the past years have shown that this …

Mechanisms of taxane resistance

SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …

Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer

C Liu, W Lou, Y Zhu, JC Yang, N Nadiminty… - Cancer research, 2015 - AACR
The introduction of enzalutamide and abiraterone has led to improvement in the treatment of
metastatic castration-resistant prostate cancer. However, acquired resistance to …

Plant flavone apigenin: an emerging anticancer agent

E Shankar, A Goel, K Gupta, S Gupta - Current pharmacology reports, 2017 - Springer
Research in cancer chemoprevention provides convincing evidence that increased intake of
vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals …

Reversal of multidrug resistance in cancer by multi-functional flavonoids

Q Ye, K Liu, Q Shen, Q Li, J Hao, F Han… - Frontiers in …, 2019 - frontiersin.org
Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one
of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have …

Mechanisms of resistance to systemic therapy in metastatic castration-resistant prostate cancer

G Galletti, BI Leach, L Lam, ST Tagawa - Cancer treatment reviews, 2017 - Elsevier
Patients with metastatic castration-resistant prostate cancer (mCPRC) now have an
unprecedented number of approved treatment options, including chemotherapies …

The flavonoid apigenin reduces prostate cancer CD44+ stem cell survival and migration through PI3K/Akt/NF-κB signaling

S Erdogan, O Doganlar, ZB Doganlar, R Serttas… - Life sciences, 2016 - Elsevier
Abstract Aims Cancer stem cells (CSCs) are involved in drug resistance, metastasis and
recurrence of cancers. The efficacy of apigenin on cell survival, apoptosis, migration and …

Key genes and molecular mechanisms related to Paclitaxel Resistance

AI Alalawy - Cancer cell international, 2024 - Springer
Paclitaxel is commonly used to treat breast, ovarian, lung, esophageal, gastric, pancreatic
cancer, and neck cancer cells. Cancer recurrence is observed in patients treated with …