Induced pluripotent stem cells from farm animals

Y Su, J Zhu, S Salman, Y Tang - Journal of animal science, 2020 - academic.oup.com
The development of the induced pluripotent stem cells (iPSC s) technology has
revolutionized the world on the establishment of pluripotent stem cells (PSC s) across a …

The use of induced pluripotent stem cells in domestic animals: a narrative review

RA Scarfone, SM Pena, KA Russell, DH Betts… - BMC veterinary …, 2020 - Springer
Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the
ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly …

Efficient derivation of transgene-free porcine induced pluripotent stem cells enables in vitro modeling of species-specific developmental timing

JV Conrad, S Meyer, PS Ramesh, JA Neira… - Stem Cell Reports, 2023 - cell.com
Sus scrofa domesticus (pig) has served as a superb large mammalian model for biomedical
studies because of its comparable physiology and organ size to humans. The derivation of …

Induced pluripotent stem cells of endangered avian species

M Katayama, T Fukuda, T Kaneko, Y Nakagawa… - Communications …, 2022 - nature.com
The number of endangered avian-related species increase in Japan recently. The
application of new technologies, such as induced pluripotent stem cells (iPSCs), may …

Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system

J Xu, L Yu, J Guo, J Xiang, Z Zheng, D Gao… - Stem Cell Research & …, 2019 - Springer
Background Pigs have emerged as one of the most popular large animal models in
biomedical research, which in many cases is considered as a superior choice over rodent …

Preserving self-renewal of porcine pluripotent stem cells in serum-free 3i culture condition and independent of LIF and b-FGF cytokines

Y Ma, T Yu, Y Cai, H Wang - Cell death discovery, 2018 - nature.com
Derivation of bona fide porcine pluripotent stem cells is still a critical issue because porcine
embryonic stem cells (ESCs) are not available yet, and most of the culture conditions to …

Porcine primordial germ cell-like cells generated from induced pluripotent stem cells under different culture conditions

NCG Pieri, AF de Souza, RC Botigelli… - Stem Cell Reviews and …, 2022 - Springer
Culture conditions regulate the process of pluripotency acquisition and self-renewal. This
study aimed to analyse the influence of the in vitro environment on the induction of porcine …

Histone lysine demethylases KDM5B and KDM5C modulate genome activation and stability in porcine embryos

WG Glanzner, K Gutierrez, VB Rissi… - Frontiers in cell and …, 2020 - frontiersin.org
The lysine demethylases KDM5B and KDM5C are highly, but transiently, expressed in
porcine embryos around the genome activation stage. Attenuation of KDM5B and KDM5C …

Epigenetic regulation of BAF60A determines efficiency of miniature swine iPSC generation

H Jiao, MS Lee, A Sivapatham, EM Leiferman… - Scientific Reports, 2022 - nature.com
Miniature pigs are an ideal animal model for translational research to evaluate stem cell
therapies and regenerative applications. While the derivation of induced pluripotent stem …

Large animal models for the clinical application of human induced pluripotent stem cells

X Cong, SM Zhang, MW Ellis, J Luo - Stem Cells and Development, 2019 - liebertpub.com
Induced pluripotent stem cell (iPSC) technology offers a practically infinite and ethically
acceptable source to obtain a variety of somatic cells. Coupled with the biotechnologies of …