Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

Norepinephrine (NE) is synthesized in the locus coeruleus and widely projected throughout
the brain and spinal cord. It regulates various actions and consciousness linked to a variety …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …

Impaired activation and regulation of the extinction of inflammatory cells and molecules in
injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly …

Astrocytes in the adult brain show cellular plasticity; however, whether they have the
potential to generate multiple lineages remains unclear. Here, we perform in vivo screens …

A holy grail of regenerative medicine is to replenish the cells that are lost due to disease.
The adult mammalian central nervous system (CNS) has, however, largely lost such a …

Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …

The inability of damaged neurons to regenerate within the mature central nervous system
(CNS) is a significant neuroscientific challenge. Astrocytes are an essential component of …