Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting
in elevated cost for public health systems. DN is the main cause of chronic kidney disease …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease and affects a large
number of individuals with diabetes. However, the development of specific treatments for DN …

It is clear that the well-described phenomenon of epithelial–mesenchymal transition (EMT)
plays a pivotal role in embryonic development, wound healing, tissue regeneration, organ …

Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with
the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of …

Skeletal homeostasis is determined by systemic hormones and local factors. Bone
morphogenetic proteins (BMPs) are unique because they induce the commitment of …

Developmental processes are regulated by the bone morphogenetic protein (BMP) family of
secreted molecules. BMPs bind to serine/threonine kinase receptors and signal through the …

Idiopathic Pulmonary Fibrosis: Aberrant Recapitulation of Developmental Programs? | PLOS
Medicine Skip to main content Advertisement PLOS Medicine Browse Current Issue Journal …