Purpose: Breast cancer in men is uncommon; 1500 new cases are diagnosed in the United
States yearly. Optimal management of breast cancer in men is unknown because the rarity …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …

The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage
and mutation analysis in 237 families, each with at least four cases of breast cancer …

Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …

Fanconi anemia (FA) is a rare autosomal recessive cancer susceptibility disorder
characterized by cellular hypersensitivity to mitomycin C (MMC). Six FA genes have been …

Breast cancer–susceptibility genes BRCA1 and BRCA2 have recently been identified on the
human genome. Women who carry a mutation of one of these genes have a greatly …

Background: In women with a family history of breast cancer, bilateral prophylactic
mastectomy is associated with a decreased risk of subsequent breast cancer of …

D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective
weight loss drugs, but was withdrawn from clinical use because of reports of cardiac …

Mutation of BRCA2 causes familial early onset breast and ovarian cancer. BRCA2 has been
suggested to be important for the maintenance of genome integrity and to have a role in …