Advances in predictions of oral bioavailability of candidate drugs in man with new machine learning methodology
U Fagerholm, S Hellberg, O Spjuth - Molecules, 2021 - mdpi.com
Oral bioavailability (F) is an essential determinant for the systemic exposure and dosing
regimens of drug candidates. F is determined by numerous processes, and computational …
regimens of drug candidates. F is determined by numerous processes, and computational …
[PDF][PDF] Utility of hepatocellular systems to measure drug transport and metabolism for prediction of in vivo drug clearance
J Harrison - 2018 - research.manchester.ac.uk
As highlighted in Chapter 1, prediction of in vivo drug PK has become an important aspect of
the drug discovery process, leading to the development of an array of in vitro methodologies …
the drug discovery process, leading to the development of an array of in vitro methodologies …