The use of effective regimens for mitigating pain remain underutilized in research rodents
despite the general acceptance of both the ethical imperative and regulatory requirements …

Pharmacological treatment is not very effective for neuropathic pain (NP). A progressive
decrease in the estimated effect of NP drugs has been reported, giving rise to an increase in …

Primary damage or dysfunction of the nervous system may cause or initiate neuropathic
pain. However, it has been difficult to establish an effective treatment for neuropathic pain …

Objective (s): Several lines of evidence showed that minocycline possesses antioxidant and
anti-inflammatory properties. This study aimed to demonstrate the effects of minocycline in …

This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Neuropathic ocular pain is a frequent occurrence in medium to severe dry eye disease
(DED). Only palliative treatments, such as lubricants and anti-inflammatory drugs, are …

Undoubtedly, opioid drugs have been the most popular treatment for refractory pain since
found, such as morphine. However, tolerance to the analgesic effects caused by repeated …

Diabetic neuropathy (DN) is the highly occurred complication of diabetes mellitus; it has
been defined as an event of peripheral nerve dysfunction characterized by pain, allodynia …

Antioxidants have been tested to treat neuropathic pain, and α-Tocopherol (vitamin E—vit.
E) and ascorbic acid (vitamin C—vit. C) are potent antioxidants. We assessed the effect of …

Altered pain sensations such as hyperalgesia and allodynia are characteristic features of
various pain states, and remain difficult to treat. We have shown previously that spinal …