Translational control in virus-infected cells

N Stern-Ginossar, SR Thompson… - Cold Spring …, 2019 - cshperspectives.cshlp.org
As obligate intracellular parasites, virus reproduction requires host cell functions. Despite
variations in genome size and configuration, nucleic acid composition, and their repertoire of …

Translational recoding: canonical translation mechanisms reinterpreted

MV Rodnina, N Korniy, M Klimova, P Karki… - Nucleic acids …, 2020 - academic.oup.com
During canonical translation, the ribosome moves along an mRNA from the start to the stop
codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein …

Modulation of viral programmed ribosomal frameshifting and stop codon readthrough by the host restriction factor shiftless

S Napthine, CH Hill, HCM Nugent, I Brierley - Viruses, 2021 - mdpi.com
The product of the interferon-stimulated gene C19orf66, Shiftless (SHFL), restricts human
immunodeficiency virus replication through downregulation of the efficiency of the viral …

Monitoring translation in all reading frames downstream of weak stop codons provides mechanistic insights into the impact of nucleotide and cellular contexts

G Loughran, X Li, S O'Loughlin, JF Atkins… - Nucleic Acids …, 2023 - academic.oup.com
A stop codon entering the ribosome A-site is normally decoded by release factors that
induce release of the polypeptide. Certain factors influence the efficiency of the termination …

Increased expression of tryptophan and tyrosine tRNAs elevates stop codon readthrough of reporter systems in human cell lines

P Beznosková, L Bidou, O Namy… - Nucleic Acids …, 2021 - academic.oup.com
Regulation of translation via stop codon readthrough (SC-RT) expands not only tissue-
specific but also viral proteomes in humans and, therefore, represents an important subject …

Entomological assessment of the status and risk of mosquito-borne arboviral transmission in Ghana

M Amoa-Bosompem, D Kobayashi, K Murota… - Viruses, 2020 - mdpi.com
Entomological surveillance is one of the tools used in monitoring and controlling vector-
borne diseases. However, the use of entomological surveillance for arboviral infection vector …

The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection

N Jäger, SA Ayyub, F Peske, D Liedtke, J Bohne… - Viruses, 2024 - mdpi.com
The interferon-induced host cell protein Shiftless (SFL) inhibits− 1 programmed ribosomal
frameshifting (− 1PRF) required for the expression of HIV-1 Gal-Pol and the formation of …

Prevention of dsRNA‐induced interferon signaling by AGO1x is linked to breast cancer cell proliferation

S Ghosh, JC Guimaraes, M Lanzafame… - The EMBO …, 2020 - embopress.org
Translational readthrough, ie, elongation of polypeptide chains beyond the stop codon, was
initially reported for viral RNA, but later found also on eukaryotic transcripts, resulting in …

The Involvement of YNR069C in Protein Synthesis in the Baker's Yeast, Saccharomyces cerevisiae

S Takallou, M Hajikarimlou, M Al-Gafari, J Wang… - Biology, 2024 - mdpi.com
Simple Summary Preserving the integrity of protein biosynthesis involves maintaining a
delicate equilibrium between translation accuracy and speed. In the current study we …

An RNA element that facilitates programmed ribosomal readthrough in turnip crinkle virus adopts multiple conformations

MM Kuhlmann, M Chattopadhyay, VA Stupina… - Journal of …, 2016 - Am Soc Microbiol
Ribosome recoding is used by RNA viruses for translational readthrough or frameshifting
past termination codons for the synthesis of extension products. Recoding sites, along with …