The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
Understanding the language of Lys36 methylation at histone H3
EJ Wagner, PB Carpenter - Nature reviews Molecular cell biology, 2012 - nature.com
Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
histone H3 (H3K36). Several enzymes from yeast and humans, including the …
[HTML][HTML] Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
[HTML][HTML] The role of chromatin during transcription
Chromatin structure imposes significant obstacles on all aspects of transcription that are
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …
mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated …
[HTML][HTML] Distinct epigenomic landscapes of pluripotent and lineage-committed human cells
Human embryonic stem cells (hESCs) share an identical genome with lineage-committed
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …
cells, yet possess the remarkable properties of self-renewal and pluripotency. The diverse …
[HTML][HTML] A chromatin landmark and transcription initiation at most promoters in human cells
We describe the results of a genome-wide analysis of human cells that suggests that most
protein-coding genes, including most genes thought to be transcriptionally inactive …
protein-coding genes, including most genes thought to be transcriptionally inactive …
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression
A Shilatifard - Annu. Rev. Biochem., 2006 - annualreviews.org
It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …
one cell generation to the next. It has been demonstrated during the past decade that the …
Histone and chromatin cross-talk
W Fischle, Y Wang, CD Allis - Current opinion in cell biology, 2003 - Elsevier
Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …
Regulation of histone methylation by demethylimination and demethylation
Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …
Differential chromatin marking of introns and expressed exons by H3K36me3
Variation in patterns of methylations of histone tails reflects and modulates chromatin
structure and function. To provide a framework for the analysis of chromatin function in …
structure and function. To provide a framework for the analysis of chromatin function in …