Summary IPC, RIPC, and IPC mimetics have the potential to be therapeutic in various
clinical scenarios. Further understanding of IPC-induced neuroprotection pathways and …

Aims The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the
mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the …

The quote “what does not kill you makes you stronger” perfectly describes the
preconditioning phenomenon–a paradigm that affords robust brain tolerance in the face of …

Aim: To investigate the protective effects of ginsenoside Rb 3, a triterpenoid saponin isolated
from the leaves of Panax notoginseng, on ischemic and reperfusion injury model of PC12 …

Ischemic stroke is a severe cause of disability and death all over the world. To search for
effective therapy for ischemic stroke, PC12 cells damaged by oxygenation and glucose …

Noise exposure at high intensities leads to a temporary shift of hearing thresholds (TTS) and
is followed by a permanent threshold shift (PTS). Permanent threshold shift is not only …

Zinc ion is essential for normal brain function that modulates synaptic activity and neuronal
plasticity and it is associated with memory formation. Zinc is considered to be a contributing …

Stroke, or cerebral ischemia (CI), remains a leading cause of mortality, however, available
therapeutics are limited. A major contributor to the pathophysiology of CI is oxidative stress …

Neurons in the mammalian central nervous system are extremely vulnerable to oxygen
deprivation and blood supply insufficiency. Hypoxia/ischemia can produce considerably …

L'ADOA-1 (Autosomal dominant optic atrophy) est une maladie neurologique pouvant être
causée par la mutation de la protéine mitochondriale OPA1 (Optic atrophy type 1) et pouvant …