D Van Morckhoven, N Dubois, D Bron… - Frontiers in …, 2023 - frontiersin.org
Following their discovery at the end of the 20th century, extracellular vesicles (EVs) ranging from 50-1,000 nm have proven to be paramount in the progression of many cancers …
JY Noh - International Journal of Molecular Sciences, 2021 - mdpi.com
Platelets play a critical role in hemostasis and thrombus formation. Platelets are small, anucleate, and short-lived blood cells that are produced by the large, polyploid, and …
Myeloproliferative neoplasms (MPNs) are rare, clonal disorders of the hematopoietic stem cell in which an uncontrolled proliferation of terminally differentiated myeloid cells is noted …
N Polverelli, EM Elli, E Abruzzese… - British journal of …, 2021 - Wiley Online Library
Ruxolitinib (RUX), the first JAK1/JAK2 inhibitor approved for myelofibrosis (MF) therapy, has recently been associated with the occurrence of second primary malignancies (SPMs) …
Simple Summary Extracellular vesicles (EVs) are released by the majority of cell types and can be isolated from both cell cultures and body fluids. They are involved in cell-to-cell …
Myelofibrosis (MF) is characterized by chronic inflammation and hyper-activation of the JAK- STAT pathway. Infections are one of the main causes of morbidity/mortality. Therapy with …
Platelet‐derived extracellular vesicles (PEVs) were originally studied for their potential as regulators of coagulation, a function redundant with that of their parent cells. However, as …
C Karantanou, VR Minciacchi… - International journal of …, 2022 - mdpi.com
Myeloid neoplasms arise from malignant primitive cells, which exhibit growth advantage within the bone marrow microenvironment (BMM). The interaction between these malignant …
L Catani, M Cavo, F Palandri - Cells, 2021 - mdpi.com
Myeloproliferative Neoplasms (MPN) are acquired clonal disorders of the hematopoietic stem cells and include Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis …