Recent advances in polycaprolactones for anticancer drug delivery

A Bhadran, T Shah, GK Babanyinah, H Polara… - Pharmaceutics, 2023 - mdpi.com
Poly (ε-Caprolactone) s are biodegradable and biocompatible polyesters that have gained
considerable attention for drug delivery applications due to their slow degradation and ease …

Macromolecular architectural effects on solution self-assembly of amphiphilic AB-type block copolymers

N Ozawa, T Nishimura - Polymer Chemistry, 2024 - pubs.rsc.org
Polymers with different architectures, such as block, graft, star, and cyclic polymers, have
been developed owing to recent advances in synthetic technology. Notably, minor changes …

Toxicity of polymeric nanodrugs as drug carriers

AB Sairam, A Sanmugam, A Pushparaj… - ACS Chemical Health …, 2023 - ACS Publications
The ambiguity of certain diseases and the potential toxicity of many medications have
sparked demand for the incorporation and enhancement of drug delivery systems (DDSs) …

Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery

GK Babanyinah, A Bhadran, H Polara, H Wang… - Chemical …, 2024 - pubs.rsc.org
High glutathione production is known to be one of the defense mechanisms by which many
cancer cells survive elevated oxidative stress. By explicitly targeting glutathione in these …

Zwitterionic Strategy to Stabilize Self‐Immolative Polymer Nanoarchitecture under Physiological pH for Drug Delivery In Vitro and In Vivo

S Pathan, M Jayakannan - Advanced Healthcare Materials, 2024 - Wiley Online Library
The major bottleneck in using polymer nanovectors for biomedical application, particularly
those based on self‐immolative poly (amino ester)(PAE), lies in their uncontrolled …

[HTML][HTML] Innovative gelatin-based micelles with AS1411 aptamer targeting and reduction responsiveness for doxorubicin delivery in tumor therapy

J Yu, Y Zhang, M Xu, D Jiang, W Liu, H Jin… - Biomedicine & …, 2024 - Elsevier
Herein, we constructed innovative reduction-sensitive and targeted gelatin-based micelles
for doxorubicin (DOX) delivery in tumor therapy. AS1411 aptamer-modified gelatin-ss …

Precision Synthesis of Ultrastable Hydrophilic Metal Nanocluster Assemblies

W Zhang, Y Shi, J Zhang, G Shi, X Qiao, Y He… - …, 2024 - ACS Publications
The directed self-assembly strategy endows the ultrasmall metal nanocluster (MNC,< 3 nm)
superstructure assemblies with enhancement of inherent characteristics or generation of …

Biotinylated Theranostic Amphiphilic Polyurethane for Targeted Drug Delivery

S Bag, MP Gadpayle, D Ghosh, S Maiti… - Biomacromolecules, 2024 - ACS Publications
In the area of drug delivery aided by stimuli-responsive polymers, the biodegradability of
nanocarriers is one of the major challenges that needs to be addressed with the utmost …

Rationally designed block copolymer-based nanoarchitectures: An emerging paradigm for effective drug delivery

R Sharma, P Shrivastava, L Gautam, U Agrawal… - Drug Discovery …, 2023 - Elsevier
Highlights•Block copolymer-based nanomedicine has emerged as an intriguing class of
therapeutic materials.•Owing to their outstanding characteristics block copolymers have …

Star-polymer unimolecular micelle nanoparticles to deliver a payload across the blood–brain barrier

M Malhotra, M Pardasani, S Pathan, P Srikanth… - Nanoscale, 2024 - pubs.rsc.org
Nanocarrier-mediated therapeutic delivery to brain tissue is impeded by tightly controlled
transportation across the blood–brain barrier (BBB). Herein, we report a well-defined core …