Genetic regulation of m6A RNA methylation and its contribution in human complex diseases
K Chen, J Nan, X Xiong - Science China Life Sciences, 2024 - Springer
Abstract N 6-methyladenosine (m6A) has been established as the most prevalent chemical
modification in message RNA (mRNA), playing an essential role in determining the fate of …
modification in message RNA (mRNA), playing an essential role in determining the fate of …
m6A modification of mutant huntingtin RNA promotes the biogenesis of pathogenic huntingtin transcripts
A Pupak, I Rodríguez-Navarro, K Sathasivam… - EMBO …, 2024 - embopress.org
In Huntington's disease (HD), aberrant processing of huntingtin (HTT) mRNA produces
HTT1a transcripts that encode the pathogenic HTT exon 1 protein. The mechanisms behind …
HTT1a transcripts that encode the pathogenic HTT exon 1 protein. The mechanisms behind …