Pathologic myopia is a major cause of visual impairment worldwide. Pathologic myopia is
distinctly different from high myopia. High myopia is a high degree of myopic refractive error …

For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …

Reduced glomerular filtration rate defines chronic kidney disease and is associated with
cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as
their precursor cholesterol are required for successful establishment and maintenance of …

There is currently an unmet need for better biomarkers across the spectrum of renal
diseases. In this paper, we revisit the role of beta-2 microglobulin (β2M) as a biomarker in …

Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …

The corpus callosum is the largest fibre tract in the brain, connecting the two cerebral
hemispheres, and thereby facilitating the integration of motor and sensory information from …

Neural stem cells (NSCs) contribute to plasticity and repair of the adult brain. Niches
harboring NSCs regulate stem cell self-renewal and differentiation. We used comprehensive …