Our understanding of the genetic basis of the Philadelphia chromosome-negative
myeloproliferative neoplasms (MPNs) has moved forward at a staggering pace over the last …

Defining the transcriptomic identity of malignant cells is challenging in the absence of
surface markers that distinguish cancer clones from one another, or from admixed non …

A quarter of patients with essential thrombocythemia or primary myelofibrosis carry a driver
mutation of CALR, the calreticulin gene. A 52-bp deletion (type 1) and a 5-bp insertion (type …

Mutations in the gene for calreticulin (CALR) were identified in the myeloproliferative
neoplasms (MPNs) essential thrombocythaemia (ET) and primary myelofibrosis (MF) in …

Simple Summary There is growing evidence that Ph-negative myeloproliferative neoplasms
are disorders in which multiple signaling pathways are significantly disturbed. The …

Calcium is one of the most important second messengers and its intracellular signaling
regulates many aspects of cell physiology. Calcium ions, like phosphate ions, are highly …

Calreticulin is a Ca2+-binding chaperone protein, which resides mainly in the endoplasmic
reticulum but also found in other cellular compartments including the plasma membrane. In …

Myeloproliferative neoplasms (MPNs) are a set of chronic hematopoietic neoplasms with
overlapping clinical and molecular features. Recent years have witnessed considerable …

Calreticulin from parasites and its vertebrate hosts share~ 50% identity and many of its
functions are equally conserved. However, the existing amino acid differences can affect its …

Mutations in the calreticulin gene (CALR) were recently identified in approximately 70–80%
of patients with JAK2‐V617F‐negative essential thrombocytosis and primary myelofibrosis …