Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

HIV-associated cancers and lymphoproliferative disorders caused by Kaposi sarcoma herpesvirus and Epstein-Barr virus

KA Lurain, R Ramaswami, LT Krug… - Clinical Microbiology …, 2024 - journals.asm.org
Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

Epstein–Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection

P Mrozek-Gorska, A Buschle, D Pich… - Proceedings of the …, 2019 - National Acad Sciences
Epstein–Barr virus (EBV) is a human tumor virus and a model of herpesviral latency. The
virus efficiently infects resting human B lymphocytes and induces their continuous …

Epstein-Barr virus LMP1-mediated oncogenicity

LW Wang, S Jiang, BE Gewurz - Journal of virology, 2017 - Am Soc Microbiol
Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human
malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression …

Epstein-Barr virus oncoprotein super-enhancers control B cell growth

H Zhou, SCS Schmidt, S Jiang, B Willox, K Bernhardt… - Cell host & …, 2015 - cell.com
Super-enhancers are clusters of gene-regulatory sites bound by multiple transcription
factors that govern cell transcription, development, phenotype, and oncogenesis. By …

Mechanisms of B-cell oncogenesis induced by Epstein-Barr virus

A Saha, ES Robertson - Journal of Virology, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus which asymptomatically infects
the majority of the world population. Under immunocompromised conditions, EBV can …

Epstein–Barr virus-associated malignancies: Roles of viral oncoproteins in carcinogenesis

A El-Sharkawy, L Al Zaidan, A Malki - Frontiers in oncology, 2018 - frontiersin.org
The Epstein–Barr virus (EBV) is the first herpesvirus identified to be associated with human
cancers known to infect the majority of the world population. EBV-associated malignancies …

CRISPR/Cas9 screens reveal Epstein-Barr virus-transformed B cell host dependency factors

Y Ma, MJ Walsh, K Bernhardt, CW Ashbaugh… - Cell host & …, 2017 - cell.com
Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (BL) and immunosuppression-
related lymphomas. These B cell malignancies arise by distinct transformation pathways and …

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

IS Pateras, S Havaki, X Nikitopoulou, K Vougas… - Pharmacology & …, 2015 - Elsevier
The characteristic feature of healthy living organisms is the preservation of homeostasis.
Compelling evidence highlight that the DNA damage response and repair (DDR/R) and …

The Epstein-Barr virus regulome in lymphoblastoid cells

S Jiang, H Zhou, J Liang, C Gerdt, C Wang, L Ke… - Cell host & …, 2017 - cell.com
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell
lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV …