Abstract N-acetyl-L-cysteine (NAC) is a compound of increasing interest in the treatment of
psychiatric disorders. Primarily through its antioxidant, anti-inflammatory, and glutamate …

Substance use disorder (SUD) is a chronic brain condition, with compulsive and
uncontrollable drug-seeking that leads to long-lasting and harmful consequences. The …

Women have more difficulty maintaining smoking cessation than men, and experience
greater withdrawal symptomatology as well as higher prevalence of relapse. Further …

Cannabis is the most widely used illicit drug worldwide, and it is estimated that up to 30% of
people who use cannabis will develop a cannabis use disorder (CUD). Demand for …

Cannabis use disorder (CUD) is a growing public health concern, with rising prevalence and
significant impact on individuals across age groups. This systematic review examines 24 …

Abstract Background and Aim Cannabis is the most consumed illicit drug globally, with a
high risk of developing cannabis use disorder (CUD). No approved pharmacological …

Increasing evidence suggests that individuals with alcohol use disorder (AUD) present with
a disrupted glutamatergic system that underlies core components of addictive disorders …

Substance dependence represents a pervasive global concern within the realm of public
health. Presently, it is delineated as a persistent and recurrent neurological disorder …

Rationale Glutamate systems play an important role in the abuse related effects of alcohol. n-
Acetylcysteine, a drug that promotes glutamate homeostasis, attenuates a range of alcohol …

Background In the late nineteenth and early twentieth centuries, cannabis in the United
States was mostly restricted to medical use, including for the management of pain …