Advances in soft mist inhalers
ABSTRACT Introduction Soft mist inhalers (SMIs) are propellant-free inhalers that utilize
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …
mechanical power to deliver single or multiple doses of inhalable drug aerosols in the form …
Use of computational fluid dynamics deposition modeling in respiratory drug delivery
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
Scientific and regulatory activities initiated by the US food and drug administration to foster approvals of generic dry powder inhalers: bioequivalence perspective
Regulatory science for generic dry powder inhalers (DPIs) in the United States (US) has
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
[HTML][HTML] SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry
When an infected person coughs, many virus-laden droplets will be exhaled out of the
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
mouth. Droplets from deep lungs are especially infectious because the alveoli are the major …
In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation
SP Newman, HK Chan - Advanced Drug Delivery Reviews, 2020 - Elsevier
Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …
A particle technology approach toward designing dry-powder inhaler formulations for personalized medicine in respiratory diseases
K Kadota, TR Sosnowski, S Tobita, I Tachibana… - Advanced Powder …, 2020 - Elsevier
Compared with oral and parenteral formulations, inhaled formulations are attractive because
of their great benefit and potential to enhance therapeutic effects of medications. Among the …
of their great benefit and potential to enhance therapeutic effects of medications. Among the …
Devices for improved delivery of nebulized pharmaceutical aerosols to the lungs
Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …
aerosols, including the use of aqueous formulations and the ability to deliver process …
High-efficiency dry powder aerosol delivery to children: Review and application of new technologies
While dry powder aerosol formulations offer a number of advantages, their use in children is
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …
In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols
In vitro-in vivo correlation is the establishment of a predictive relationship between in vitro
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
and in vivo data. In the context of cascade impactor results of orally inhaled pharmaceutical …
Spray drying: Inhalable powders for pulmonary gene therapy
Gene therapy holds potential in the treatment of many lung pathologies, as indicated by the
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …
growing number of clinical trials in recent decades. Pulmonary delivery of gene therapies via …