E De Clercq - Chemistry & biodiversity, 2004 - Wiley Online Library
Non‐nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent ingredient of the drug combination schemes that are currently used in the treatment of …
JB Jackson, P Musoke, T Fleming, LA Guay… - The Lancet, 2003 - thelancet.com
Background In 1999, we reported safety and efficacy data for short-course nevirapine from a Ugandan perinatal HIV-1 prevention trial when 496 babies were followed up to age 14–16 …
Background Although zidovudine prophylaxis decreases the rate of transmission of the human immunodeficiency virus (HIV) type 1 substantially, a large number of infants still …
The World Health Organization (WHO) defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”. Thus, in …
BACKGROUND: Large reductions in transmission of HIV-1 from mother to child have been achieved in more-developed countries due to the use of antiretrovirals. Short-course …
MS Hirsch, F Brun-Vézinet, B Clotet… - Clinical Infectious …, 2003 - academic.oup.com
New information about the benefits and limitations of testing for resistance to human immunodeficiency virus (HIV) type 1 (HIV-1) drugs has emerged. The International AIDS …
L Mandelbrot, A Landreau-Mascaro, C Rekacewicz… - Jama, 2001 - jamanetwork.com
ContextZidovudine reduces maternal-infant transmission of human immunodeficiency virus 1 (HIV-1) infection by two thirds. Combination antiretroviral therapies are potentially more …
Objective: To compare the prevalence of resistance by adherence level in patients treated with non-nucleoside reverse transcriptase inhibitors (NNRTI) or protease inhibitors (PI). Also …
SH Eshleman, M Mracna, LA Guay, M Deseyve… - Aids, 2001 - journals.lww.com
Objective To examine the emergence and fading of NVP resistance (NVP R) mutations in HIV-1-infected Ugandan women and infants who received single dose NVP to prevent HIV-1 …