Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Metabolomics is becoming common in epidemiology due to recent developments in
quantitative profiling technologies and appealing results from their applications for …

Background—High-throughput profiling of circulating metabolites may improve
cardiovascular risk prediction over established risk factors. Methods and Results—We …

Physical activity (PA) and exercise are among the most important determinants of health.
However, PA is a complex and heterogeneous behavior and the biological mechanisms …

Recent studies suggest that exercise alters the gut microbiome. We determined whether six-
weeks endurance exercise, without changing diet, affected the gut metagenome and …

Physical activity is essential in weight management, improves overall health, and mitigates
obesity-related risk markers. Besides inducing changes in systemic metabolism, habitual …

Background We hypothesized that a fully automated mobile health (mH ealth) intervention
with tracking and texting components would increase physical activity. Methods and Results …

Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We
aimed to determine to what extent elevated body mass index (BMI) within the normal weight …

Background Early identification of ambulatory persons at high short-term risk of death could
benefit targeted prevention. To identify biomarkers for all-cause mortality and enhance risk …

OBJECTIVE Insulin resistance has deleterious effects on cardiometabolic disease. We used
Mendelian randomization analyses to clarify the causal relationships of insulin resistance …