Current and emerging treatment options for uterine fibroids

M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …

Contemporary approaches in the management of uterine leiomyomas

S Singh, P Kumar, SS Rathore, Y Singh… - European Journal of …, 2023 - Elsevier
Background Leiomyomas (fibroids), the most common benign solid tumours in females,
originate from the myometrium and are associated with poor quality of life for patients. The …

Pharmacokinetics, toxicological and clinical aspects of ulipristal acetate: insights into the mechanisms implicated in the hepatic toxicity

RJ Dinis-Oliveira - Drug Metabolism Reviews, 2021 - Taylor & Francis
Ulipristal acetate is a drug used as emergency contraceptive (30 mg) and for the treatment of
moderate to severe symptoms of uterine myomas (5 mg). After commercialization, and …

Onapristone extended release: Safety evaluation from phase I–II studies with an emphasis on hepatotoxicity

JH Lewis, PH Cottu, M Lehr, E Dick, T Shearer… - Drug Safety, 2020 - Springer
Introduction Antiprogestins have demonstrated promising activity against breast and
gynecological cancers, but liver-related safety concerns limited the advancement of this …

Evaluation of ovulation and safety outcomes in a multi-center randomized trial of three 84 day ulipristal acetate regimens

CL Westhoff, DF Archer, K Barnhart, P Darney… - Contraception, 2022 - Elsevier
Objectives: To describe ovulation inhibition and safety of daily oral ulipristal acetate (UPA)
over 84 days. Study Design: This multi-center phase 1 and/or 2 trial randomized participants …

Kaempferol modulates ɑ2M secretion in bone marrow-derived macrophages by downregulating GR/PER1-mediated lipid metabolism to attenuate the emotional …

W Li, H Liu, J Zheng, D Wang, Z Wang, M Hong… - Journal of …, 2025 - Elsevier
Ethnopharmacological relevance Prostate cancer patients often suffer from depression
during androgen deprivation therapy. Chaihu-Shugan-San (CSS) can prevent prostate …

The progesterone-receptor modulator, ulipristal acetate, drastically lowers breast cell proliferation

CL Westhoff, H Guo, Z Wang, H Hibshoosh… - Breast cancer research …, 2022 - Springer
Purpose The proliferation of breast epithelial cells increases during the luteal phase of the
menstrual cycle, when they are exposed to progesterone, suggesting that ulipristal acetate …

[HTML][HTML] Proteins involved in oxidative stress in leiomyoma tissues treated with ulipristal acetate

B Ura, L Monasta… - Molecular …, 2021 - spandidos-publications.com
Uterine leiomyoma presents the highest incidence among benign tumors of the female
reproductive tract. The present study compared the proteome of leiomyoma treated with …

[HTML][HTML] The endometrial response to modulation of ligand-progesterone receptor pathways is reversible

RR Chodankar, A Murray, M Nicol, LHR Whitaker… - Fertility and …, 2021 - Elsevier
Objective To study the impact of the progesterone receptor modulator (PRM), ulipristal
acetate (UPA), on endometrial morphology and function. Design Cross-sectional. Setting …

Ulipristal Acetate (UPA) in Emergency Contraception: The Mechanism of Action, Toxicity and Perspectives

B Mozzanega - Medical Research Archives, 2022 - esmed.org
Abstract After recalling that Levonorgestrel Emergency Contraceptive Pills never delay or
suppress ovulation, but impair the luteal body functions, and, consequently, the embryo …