α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in
neurotransmission and regulate the sympathetic nervous system through binding and …

The prefrontal cortex (PFC) is deeply involved in higher brain functions, many of which are
altered in psychiatric conditions. The PFC exerts a top-down control of most cortical and …

Norepinephrine (NE) is synthesized in the Locus Coeruleus (LC) of the brainstem, from
where it is released by axonal varicosities throughout the brain via volume transmission. A …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

The chemical synapse is the principal form of contact between neurons of the central
nervous system. These synapses are typically configured as presynaptic axon terminations …

Parvalbumin interneurons (PVIs) are affected in many psychiatric disorders including
schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk …

The medial prefrontal cortex (mPFC) receives dense noradrenergic projections from the
locus coeruleus. Adrenergic innervation of mPFC pyramidal neurons plays an essential role …

Stress exposure can cause lasting changes in cognition, but certain individual traits, such as
cognitive flexibility, have been shown to reduce the degree, duration, or severity of cognitive …