Hedgehog (Hh) pathway controls complex developmental processes in vertebrates.
Abnormal activation of Hh pathway is responsible for tumorigenesis and maintenance of …

Haematopoiesis is a tightly orchestrated process where a pool of hematopoietic stem and
progenitor cells (HSPCs) with high self-renewal potential can give rise to both lymphoid and …

SOX11 overexpression in mantle cell lymphoma (MCL) has been associated with more
aggressive behavior and worse outcome. However, SOX11 oncogenic pathways driving …

Mantle cell lymphoma and other lymphoma subtypes often spread to the bone marrow, and
stromal interactions mediated by focal adhesion kinase frequently enhance survival and …

Expression of the transglutaminase TG2 has been linked to constitutive activation of NF-κB
and chemotherapy resistance in mantle cell lymphoma (MCL) cells. TG2 forms complexes …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive subtype of ALL characterized
by its high heterogeneity and unfavorable clinical features. Despite improved insights in …

Background Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with
gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI …

The recent advent of the Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)‐CRISPR associated protein 9 (Cas9) system for precise genome editing has …

Andrographolide (Andro) has emerged recently as a potential and effective anticancer agent
with induction of apoptosis in some cancer cell lines while induction of G2/M arrest with …

The prognosis of patients with multiple myeloma (MM) has improved dramatically with the
introduction of new therapeutic drugs, but the disease eventually becomes drug-resistant …