In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases
responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in …

For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Many pathogenic organisms produce pore-forming toxins as virulence factors. Target cells
however mount a response to such membrane damage. Here we show that toxin-induced …

As part of a shift toward macromolecule production to support continuous cell proliferation,
cancer cells coordinate the activation of lipid biosynthesis and the signaling networks that …

The sterol regulatory element binding protein (SREBP) family of transcription factors controls
cholesterol and lipid metabolism. The nuclear forms of these proteins are rapidly degraded …

Phosphatidylinositol 3′-kinase (PI3K) and Akt are signaling kinases involved in cell
survival and proliferation. Recent evidence suggests that PI3K/Akt activates the sterol …

The processes of cell proliferation, cell death and differentiation involve an intricate array of
biochemical and morphological changes that require a finely tuned modulation of metabolic …