Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Arginine and endothelial function

J Gambardella, W Khondkar, MB Morelli, X Wang… - Biomedicines, 2020 - mdpi.com
Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Endothelial dysfunction due to eNOS uncoupling: Molecular mechanisms as potential therapeutic targets

A Janaszak-Jasiecka, A Płoska, JM Wierońska… - Cellular & molecular …, 2023 - Springer
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Endothelial dysfunction in chronic kidney disease, from biology to clinical outcomes: a 2020 update

S Roumeliotis, F Mallamaci, C Zoccali - Journal of Clinical Medicine, 2020 - mdpi.com
The vascular endothelium is a dynamic, functionally complex organ, modulating multiple
biological processes, including vascular tone and permeability, inflammatory responses …

Endothelial cell metabolism

G Eelen, P de Zeeuw, L Treps, U Harjes… - Physiological …, 2018 - journals.physiology.org
Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Strategies to increase nitric oxide signalling in cardiovascular disease

JO Lundberg, MT Gladwin, E Weitzberg - Nature reviews Drug …, 2015 - nature.com
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Thirty years of saying NO: sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator

PM Vanhoutte, Y Zhao, A Xu, SWS Leung - Circulation research, 2016 - Am Heart Assoc
Endothelial cells control vascular tone by releasing nitric oxide (NO) produced by
endothelial NO synthase. The activity of endothelial NO synthase is modulated by the …

Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? A scientific statement from the American Heart …

PB Lockhart, AF Bolger, PN Papapanou… - Circulation, 2012 - Am Heart Assoc
A link between oral health and cardiovascular disease has been proposed for more than a
century. Recently, concern about possible links between periodontal disease (PD) and …

l-Citrulline Supplementation: Impact on Cardiometabolic Health

TD Allerton, DN Proctor, JM Stephens, TR Dugas… - Nutrients, 2018 - mdpi.com
Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in
the regulation of numerous vital biological functions, contributes to the development and …