Oxidative stress in liver pathophysiology and disease

A Allameh, R Niayesh-Mehr, A Aliarab, G Sebastiani… - Antioxidants, 2023 - mdpi.com
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection

WR García-Niño, C Zazueta - Pharmacological Research, 2015 - Elsevier
Traditional drugs or therapies rarely have effects on regression of chronic liver diseases,
which result in many cases from sustained oxidative stress. In recent years, ellagic acid (EA) …

MR image denoising and super-resolution using regularized reverse diffusion

H Chung, ES Lee, JC Ye - IEEE Transactions on Medical …, 2022 - ieeexplore.ieee.org
Patient scans from MRI often suffer from noise, which hampers the diagnostic capability of
such images. As a method to mitigate such artifacts, denoising is largely studied both within …

The thanatomicrobiome: a missing piece of the microbial puzzle of death

GT Javan, SJ Finley, Z Abidin, JG Mulle - Frontiers in microbiology, 2016 - frontiersin.org
Death is a universal phenomenon; however, is there “life after death?” This topic has been
investigated for centuries but still there are gray areas that have yet to be elucidated …

Cold atmospheric pressure plasma jet operated in Ar and He: From basic plasma properties to vacuum ultraviolet, electric field and safety thresholds measurements in …

AV Nastuta, T Gerling - Applied Sciences, 2022 - mdpi.com
Application desired functionality as well as operation expenses of cold atmospheric
pressure plasma (CAP) devices scale with properties like gas selection. The present …

An interdisciplinary review of the thanatomicrobiome in human decomposition

GT Javan, SJ Finley, S Tuomisto, A Hall… - … Science, Medicine and …, 2019 - Springer
Death does not occur instantaneously and organs do not decompose at the same rate or in
the same way. Nulligravid human uteri and prostate glands are the last internal organs to …

Exploring the therapeutic potential of targeting GH and IGF-1 in the management of obesity: Insights from the interplay between these hormones and metabolism

S Al-Samerria, S Radovick - International journal of molecular sciences, 2023 - mdpi.com
Obesity is a growing public health problem worldwide, and GH and IGF-1 have been studied
as potential therapeutic targets for managing this condition. This review article aims to …

Macrophages and the development and progression of non-alcoholic fatty liver disease

B Alabdulaali, F Al-Rashed, M Al-Onaizi… - Frontiers in …, 2023 - frontiersin.org
The liver is the site of first pass metabolism, detoxifying and metabolizing blood arriving from
the hepatic portal vein and hepatic artery. It is made up of multiple cell types, including …

Interorgan communication with the liver: novel mechanisms and therapeutic targets

J Zhao, X Zhang, Y Li, J Yu, Z Chen, Y Niu… - Frontiers in …, 2023 - frontiersin.org
The liver is a multifunctional organ that plays crucial roles in numerous physiological
processes, such as production of bile and proteins for blood plasma, regulation of blood …

A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis

B Mukhopadhyay, C Marietta, PH Shen… - Nature …, 2024 - nature.com
Only~ 20% of heavy drinkers develop alcohol cirrhosis (AC). While differences in
metabolism, inflammation, signaling, microbiome signatures and genetic variations have …