The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

The recent implementation of genomic and lipidomic approaches has produced a large
body of evidence implicating the sphingolipid ceramide in a diverse range of physiological …

Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within
hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies …

Nearly all stress stimuli (eg, inflammatory cytokines, glucocorticoids, chemotherapeutics,
etc.) induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide …

Kupffer cells have been implicated in the pathogenesis of various liver diseases. However,
their involvement in metabolic disorders of the liver, including fatty liver disease, remains …

Ceramides are signals of fatty acid excess that accumulate when a cell's energetic needs
have been met and its nutrient storage has reached capacity. As these sphingolipids accrue …

The application of lipidomics, after genomics, proteomics and metabolomics, offered largely
opportunities to illuminate the entire spectrum of lipidome based on a quantitative or semi …

Obesity is increasingly prevalent, strongly associated with nonalcoholic liver disease, and a
risk factor for numerous cancers. Here, we describe the liver-related consequences of long …