Antifungal peptides and proteins to control toxigenic fungi and mycotoxin biosynthesis

PV Martínez-Culebras, M Gandía, S Garrigues… - International Journal of …, 2021 - mdpi.com
The global challenge to prevent fungal spoilage and mycotoxin contamination on food and
feed requires the development of new antifungal strategies. Antimicrobial peptides and …

Defensins: Transcriptional regulation and function beyond antimicrobial activity

G Contreras, I Shirdel, MS Braun, M Wink - Developmental & Comparative …, 2020 - Elsevier
Defensins are one the largest group of antimicrobial peptides and are part of the innate
defence. Defensins are produced by animals, plants and fungi. In animals and plants …

RNAseq analysis reveals drought-responsive molecular pathways with candidate genes and putative molecular markers in root tissue of wheat

MA Iquebal, P Sharma, RS Jasrotia, S Jaiswal… - Scientific reports, 2019 - nature.com
Drought is one of the major impediments in wheat productivity. Traditional breeding and
marker assisted QTL introgression had limited success. Available wheat genomic and RNA …

Updating genome annotation for the microbial cell factory Aspergillus niger using gene co-expression networks

P Schaepe, MJ Kwon, B Baumann… - Nucleic acids …, 2019 - academic.oup.com
A significant challenge in our understanding of biological systems is the high number of
genes with unknown function in many genomes. The fungal genus Aspergillus contains …

Turning inside out: filamentous fungal secretion and its applications in biotechnology, agriculture, and the clinic

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Journal of Fungi, 2021 - mdpi.com
Filamentous fungi are found in virtually every marine and terrestrial habitat. Vital to this
success is their ability to secrete a diverse range of molecules, including hydrolytic enzymes …

New Antimicrobial Potential and Structural Properties of PAFB: A Cationic, Cysteine-Rich Protein from Penicillium chrysogenum Q176

A Huber, D Hajdu, D Bratschun-Khan, Z Gáspári… - Scientific Reports, 2018 - nature.com
Small, cysteine-rich and cationic proteins with antimicrobial activity are produced by diverse
organisms of all kingdoms and represent promising molecules for drug development. The …

Novel findings about the mode of action of the antifungal protein PeAfpA against Saccharomyces cerevisiae

M Giner-Llorca, A Locascio, JA Del Real… - Applied microbiology …, 2023 - Springer
Antifungal proteins (AFPs) from filamentous fungi offer the potential to control fungal
infections that threaten human health and food safety. AFPs exhibit broad antifungal spectra …

Efficient production and characterization of the novel and highly active antifungal protein AfpB from Penicillium digitatum

S Garrigues, M Gandía, C Popa, A Borics, F Marx… - Scientific reports, 2017 - nature.com
Filamentous fungi encode distinct antifungal proteins (AFPs) that offer great potential to
develop new antifungals. Fungi are considered immune to their own AFPs as occurs in …

Functional exploration of co-expression networks identifies a nexus for modulating protein and citric acid titres in Aspergillus niger submerged culture

TC Cairns, C Feurstein, X Zheng, LH Zhang… - Fungal Biology and …, 2019 - Springer
Background Filamentous fungal cell factories are used to produce numerous proteins,
enzymes, and organic acids. Protein secretion and filamentous growth are tightly coupled at …

The Penicillium chrysogenum Q176 Antimicrobial Protein PAFC Effectively Inhibits the Growth of the Opportunistic Human Pathogen Candida albicans

J Holzknecht, A Kühbacher, C Papp, A Farkas… - Journal of Fungi, 2020 - mdpi.com
Small, cysteine-rich and cationic antimicrobial proteins (AMPs) from filamentous
ascomycetes promise treatment alternatives to licensed antifungal drugs. In this study, we …