Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …

The Cl−-transporting proteins CFTR, SLC26A9, and anoctamin (ANO1; ANO6) appear to
have more in common than initially suspected, as they all participate in the pathogenic …

In autosomal dominant polycystic kidney disease (ADPKD) multiple bilateral renal cysts
gradually enlarge, leading to a decline in renal function. Transepithelial chloride secretion …

Abstract Anoctamin 3 (ANO3) belongs to a family of transmembrane proteins that form
phospholipid scramblases and ion channels. A large number of ANO3 variants were …

Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …

Polycystic kidney disease is typified by cysts in the kidney and extra-renal manifestations
including hypertension and heart failure. The main genetic underpinning this disease are …

Abstract Background Transmembrane protein 16A (TMEM16A) Ca 2+-activated Cl−
channels have diverse physiological functions, such as epithelial secretion of Cl− and fluid …

SIGIRR (single immunoglobulin IL‐1 related receptor), PKP3 (plakophilin 3), and TMEM16J
(anoctamin 9), a putative calcium‐activated ion channel and phospholipid scramblase …

This review focuses on the most recent advances in the understanding of the electrolyte
transport-related mechanisms important for the development of severe inherited renal …

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent inherited
kidney disease. Transepithelial fluid secretion is one of the key factors of cystogenesis in …