GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment

Y Xu, M Zhao, Y Han, H Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

BDNF effects on dendritic spine morphology and hippocampal function

O von Bohlen und Halbach… - Cell and tissue …, 2018 - Springer
Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …

Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice

S Nikolic, M Gazdic-Jankovic, G Rosic… - Environmental …, 2022 - Elsevier
Commercially manufactured or generated through environmental degradation, microplastics
(MPs) and nanoplastics (NPs) considerably contribute to environmental pollution. There is a …

Origin, development, and synaptogenesis of cortical interneurons

A Llorca, R Deogracias - Frontiers in Neuroscience, 2022 - frontiersin.org
The mammalian cerebral cortex represents one of the most recent and astonishing
inventions of nature, responsible of a large diversity of functions that range from sensory …

Calcium-binding proteins as determinants of central nervous system neuronal vulnerability to disease

R Fairless, SK Williams, R Diem - International journal of molecular …, 2019 - mdpi.com
Neuronal subpopulations display differential vulnerabilities to disease, but the factors that
determine their susceptibility are poorly understood. Toxic increases in intracellular calcium …

Acute pharmacological inhibition of matrix metalloproteinase‐9 activity during development restores perineuronal net formation and normalizes auditory processing in …

PS Pirbhoy, M Rais, JW Lovelace… - Journal of …, 2020 - Wiley Online Library
Abstract Individuals with Fragile X Syndrome (FXS) and autism spectrum disorder (ASD)
exhibit cognitive impairments, social deficits, increased anxiety, and sensory …

The hormesis principle of neuroplasticity and neuroprotection

MP Mattson, RK Leak - Cell Metabolism, 2024 - cell.com
Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

Hippocampal parvalbumin interneurons play a critical role in memory development

JM Miranda, E Cruz, B Bessières, CM Alberini - Cell reports, 2022 - cell.com
Episodic memories formed in early childhood rapidly decay, but their latent traces remain
stored long term. These memories require the dorsal hippocampus (dHPC) and seem to …

Auditory cortex volume and gamma oscillation abnormalities in schizophrenia

Y Hirano, N Oribe, T Onitsuka… - Clinical EEG and …, 2020 - journals.sagepub.com
We investigated whether the gray matter volume of primary auditory cortex (Heschl's gyrus
[HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely …

Impaired motor skill learning and altered seizure susceptibility in mice with loss or gain of function of the Kcnt1 gene encoding Slack (KNa1.1) Na+-activated K+ …

IH Quraishi, MR Mercier, H McClure, RL Couture… - Scientific Reports, 2020 - nature.com
Gain-of-function mutations in KCNT1, the gene encoding Slack (KNa1. 1) channels, result in
epilepsy of infancy with migrating focal seizures (EIMFS) and several other forms of epilepsy …