Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia
U Aypar, SA Smoley, BA Pitel… - European journal of …, 2019 - Wiley Online Library
Objective Acute myeloid leukemia (AML) can be subtyped based on recurrent cytogenetic
and molecular genetic abnormalities with diagnostic and prognostic significance. Although …
and molecular genetic abnormalities with diagnostic and prognostic significance. Although …
3q26.2/MECOM Rearrangements by Pericentric Inv(3): Diagnostic Challenges and Clinicopathologic Features
Simple Summary In this study, 17 acute myeloid leukemia (AML) patients were identified to
pose a pericentric inv (3) aberration with breakpoints at 3p23 (n= 11), 3p25 (n= 3), 3p21 (n …
pose a pericentric inv (3) aberration with breakpoints at 3p23 (n= 11), 3p25 (n= 3), 3p21 (n …
Comparison of myeloid neoplasms with nonclassic 3q26.2/MECOM versus classic inv(3)/t(3;3) rearrangements reveals diverse clinicopathologic features, genetic profiles, and …
J Gao, S Gurbuxani, T Zak… - Genes …, 2022 - Wiley Online Library
MECOM rearrangements are recurrent in myeloid neoplasms and associated with poor
prognosis. However, only inv (3)(q21q26. 2) and t (3; 3)(q21; q26. 2), the classic MECOM …
prognosis. However, only inv (3)(q21q26. 2) and t (3; 3)(q21; q26. 2), the classic MECOM …
MECOM gene overexpression in pediatric patients with acute myeloid leukemia
Background Acute myeloid leukemia (AML) is characterized by blocked or aberrant
differentiation of hematopoietic stem cells. The MECOM gene overexpression in …
differentiation of hematopoietic stem cells. The MECOM gene overexpression in …
[HTML][HTML] Zebrafish Foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2. 5 expression
L He, Q Zhang, D Jiang, Y Zhang, Y Wei, Y Yang… - Journal of Genetics and …, 2022 - Elsevier
Chamber maturation is a significant process in cardiac development. Disorders of this
crucial process lead to a range of congenital heart defects. Foxc1a is a critical transcription …
crucial process lead to a range of congenital heart defects. Foxc1a is a critical transcription …
Somatic homozygous loss of SH2B3, and a non-Robertsonian translocation t (15; 21)(q25. 3; q22. 1) with NTRK3 rearrangement, in an adolescent with progenitor B …
RRC de Matos, MAK Othman, GM Ferreira… - Cancer Genetics, 2022 - Elsevier
Intrachromosomal amplification of chromosome 21 (iAMP21) occurs in∼ 2% of B-cell acute
lymphoblastic leukemia (ALL) and is considered to confer a poor prognosis. The relapse risk …
lymphoblastic leukemia (ALL) and is considered to confer a poor prognosis. The relapse risk …
FISH—in Leukemia Diagnostics
R Matos, M de Souza, G Ferreira… - Cytogenetics and …, 2022 - taylorfrancis.com
Leukemia comprises a heterogeneous group of hematological neoplasias characterized by
clonal proliferation of hematopoietic cell lineages that underwent genetic alterations, leading …
clonal proliferation of hematopoietic cell lineages that underwent genetic alterations, leading …