[HTML][HTML] Maternal mineral and bone metabolism during pregnancy, lactation, and post-weaning recovery

CS Kovacs - Physiological reviews, 2016 - journals.physiology.org
During pregnancy and lactation, female physiology adapts to meet the added nutritional
demands of fetuses and neonates. An average full-term fetus contains∼ 30 g calcium, 20 g …

Parathyroid hormone-related protein, its regulation of cartilage and bone development, and role in treating bone diseases

TJ Martin - Physiological reviews, 2016 - journals.physiology.org
Although parathyroid hormone-related protein (PTHrP) was discovered as a cancer-derived
hormone, it has been revealed as an important paracrine/autocrine regulator in many …

Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the …

TL Clemens, S Cormier, A Eichinger… - British journal of …, 2001 - Wiley Online Library
The cloning of the so‐called 'parathyroid hormone‐related protein'(PTHrP) in 1987 was the
result of a long quest for the factor which, by mimicking the actions of PTH in bone and …

[PDF][PDF] Disorders of calcium: hypercalcemia and hypocalcemia

PA Schenck, DJ Chew, LA Nagode… - Fluid, electrolyte, and …, 2006 - researchgate.net
Hypocalcemia based on serum tCa is a relatively common laboratory abnormality and was
observed in 13.5% of serum biochemical profiles of dogs in one clinical study. 111 Based on …

Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting

T Massfelder, P Dann, TL Wu… - Proceedings of the …, 1997 - National Acad Sciences
Parathyroid hormone-related protein (PTHrP) is a prohormone that is posttranslationally
processed to a family of mature secretory forms, each of which has its own cognate receptor …

Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D

MJ Horwitz, MB Tedesco, SM Sereika… - Journal of Bone and …, 2005 - academic.oup.com
Abstract Osteoblast activity and plasma 1, 25 (OH) 2vitamin D are increased in HPT but
suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous …

Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen

M Iwamura, J Hellman, ATK Cockett, H Lilja… - Urology, 1996 - Elsevier
OBJECTIVES: To discover whether the proteolytic activity of prostate-specific antigen (PSA)
affects the structure and function of parathyroid hormone-related protein (PTHrP), as both …

Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation

D Lozano, M Manzano, JC Doadrio, AJ Salinas… - Acta biomaterialia, 2010 - Elsevier
Parathyroid hormone-related protein (PTHrP) is an important regulator of bone remodeling.
Recent studies show that this protein can induce osteogenic features through its N-and C …

Autocrine and paracrine regulation of the murine skeleton by osteocyte‐derived parathyroid hormone‐related protein

N Ansari, PWM Ho, B Crimeen‐Irwin… - Journal of Bone and …, 2018 - academic.oup.com
Parathyroid hormone–related protein (PTHrP) and parathyroid hormone (PTH) have N‐
terminal domains that bind a common receptor, PTHR1. N‐terminal PTH (teriparatide) and …

Structural and physiologic characterization of the mid-region secretory species of parathyroid hormone-related protein

TL Wu, RC Vasavada, K Yang, T Massfelder… - Journal of Biological …, 1996 - ASBMB
Parathyroid hormone-related protein (PTHrP) is initially translated as a preprohormone
which is posttranslationally processed to yield a family of mature secretory forms. Most …