A key component of efforts to identify the biological and drug-specific aspects contributing to
therapeutic failure or unexpected exposure-associated toxicity is the study of drug–intestinal …

Scope: Chlorogenic acid (5-caffeoylquinic acid), the most prominent polyphenolic
compound in coffee, has been attributed multiple health-promoting effects such as anti …

Solubility, lipophilicity and permeability are crucial issues determining the bioavailability of
drugs. Antiandrogens enzalutamide and apalutamide with high antitumoral activity …

Leishmaniasis is a neglected tropical disease of major public health concern. Challenges
with current therapeutics have led to the exploration of plant medicine for potential …

Short chain fatty acids (SCFA) are hypothesised to play a key role in the microbiota-gut-brain
crosstalk. However, studies that evaluate the effect of microbiota-targeted interventions, such …

The first line therapy of patients with Parkinson's disease, a neurodegenerative disorder
caused by the degeneration of dopaminergic neurons, is levodopa (L-dopa) given orally …

A cyclodextrin complex of afatinib, a FDA-approved pan–ErbB inhibitor and known P-gp
substrate, was developed to enhance its bio-activity while also reducing p-glycoprotein (P …

The permeability of saponins and sapogenins from fenugreek and quinoa extracts, as well
as dioscin and diosgenin, was evaluated by the parallel artificial membrane permeability …

Medicinal plant extracts are becoming increasingly important as an alternative for traditional
drugs against diabetes mellitus (DM). For this reason, we initialized a target-based …

Efficient telmisartan delivery for hypertension management requires the incorporation of
meglumine and/or sodium hydroxide as an alkalizer in the formulation. Long-term use of …