APOBEC-induced mutagenesis in cancer

TM Mertz, CD Collins, M Dennis… - Annual Review of …, 2022 - annualreviews.org
The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

MYBL2 amplification in breast cancer: molecular mechanisms and therapeutic potential

R Bayley, C Ward, P Garcia - Biochimica et Biophysica Acta (BBA)-Reviews …, 2020 - Elsevier
The MYBL2 gene, also known as B-MYB, is essential to regulate vital cellular processes
including cell proliferation, differentiation and DNA repair. Changes in these pathways can …

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

M Periyasamy, AK Singh, C Gemma… - Nucleic acids …, 2017 - academic.oup.com
Cancer genome sequencing has implicated the cytosine deaminase activity of
apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an …

Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B

MB Adolph, RP Love, Y Feng… - Nucleic acids research, 2017 - academic.oup.com
The single-stranded DNA cytidine deaminases APOBEC3B, APOBEC3H haplotype I, and
APOBEC3A can contribute to cancer through deamination of cytosine to form promutagenic …

Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction

A Bacolla, Z Ye, Z Ahmed, JA Tainer - Progress in biophysics and molecular …, 2019 - Elsevier
A hallmark of cancer is genomic instability, which can enable cancer cells to evade
therapeutic strategies. Here we employed a computational approach to uncover …

Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer

WC Chou, WT Chen, CT Kuo, YM Chang, YS Lu, CW Li… - Cell Reports, 2024 - cell.com
Immune checkpoint blockade (ICB) is a promising therapy for solid tumors, but its
effectiveness depends on biomarkers that are not precise. Here, we utilized genome-wide …

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis

M Gao, Z Qi, W Feng, H Huang, Z Xu, Z Dong… - Journal of Biological …, 2022 - ASBMB
The cytidine deaminase APOBEC3B (A3B) is an endogenous inducer of somatic mutations
and causes chromosomal instability by converting cytosine to uracil in single-stranded DNA …

PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 …

V Guarneri, MV Dieci, G Bisagni, AA Brandes… - Clinical Cancer …, 2020 - AACR
Purpose: We explored the prognostic effect of PIK3CA mutation in HER2+ patients enrolled
in the ShortHER trial. Patients and Methods: The ShortHER trial randomized 1,253 patients …

High MYBL2 expression and transcription regulatory activity is associated with poor overall survival in patients with hepatocellular carcinoma

Z Guan, W Cheng, D Huang, A Wei - Current research in translational …, 2018 - Elsevier
Purpose In this study, we aimed to assess the association between MYBL2 expression/
transcription regulatory activity (TRA) and overall survival (OS) in patients with primary …

Understanding the regulation of APOBEC3 expression: Current evidence and much to learn

DA Covino, MC Gauzzi, L Fantuzzi - Journal of leukocyte …, 2018 - academic.oup.com
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) family
of cytosine deaminases plays crucial roles in innate immunity through the ability of restricting …