The repair of DNA double‑strand breaks (DSBs) is crucial for the preservation of genomic
integrity and the maintenance of cellular homeostasis. Non‑homologous DNA end joining …

Triple‐negative breast cancer (TNBC) has higher molecular heterogeneity and metastatic
potential and the poorest prognosis. Because of limited therapeutics against TNBC …

The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human
diseases, as they play important roles in multiple cellular processes. In this review, we …

During the origin of great apes about 14 million years ago, a series of phenotypic
innovations emerged, such as the increased body size, the enlarged brain volume, the …

MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN
oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on …

DNA damage response (DDR) is essential for maintaining genome stability and protecting
cells from tumorigenesis. Ubiquitin and ubiquitin-like modifications play an important role in …

Maintenance of genome integrity is a precise but tedious and complex job for the cell.
Several post-translational modifications (PTMs) play vital roles in maintaining the genome …

In studies on the mechanism of DNA damage response where ionizing radiation is used as
the DNA damaging agent, cells are often exposed to ionizing radiation on melting ice …

Hepatocellular carcinoma (HCC) is one of the malignant tumors with the worst prognosis,
and tumor recurrence and metastasis are the main factors leading to poor prognosis of HCC …

Ubiquitination is a post-translational modification (PTM) that is involved in proteolysis,
protein–protein interaction, and signal transduction. Accumulation of mutations and genomic …