Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …

Objectives Even with great advances in modern medicine and therapeutic agent
development, the search for effective antidiabetic drugs remains challenging. Coumarins are …

Cancer cachexia, weight loss with altered body composition, is a multifactorial syndrome
propagated by symptoms that impair caloric intake, tumor byproducts, chronic inflammation …

Cachexia is a major characteristic of multiple non-malignant diseases, advanced and
metastatic cancers and it is highly prevalent in pancreatic cancer, affecting almost 70%–80 …

Type 2 diabetes has traditionally been viewed as a metabolic disorder characterised by
chronic high glucose levels, insulin resistance, and declining insulin secretion from the …

Aims/hypothesis Inflammation contributes to pancreatic beta cell dysfunction in type 2
diabetes. Toll-like receptor (TLR)-2 and-4 ligands are increased systemically in recently …

The discovery 30 years ago that inflammatory cytokines cause a concentration, activity, and
time-dependent bimodal response in pancreatic β-cell function and viability has been a …

In the past decade, islet inflammation has emerged as a contributor to the loss of functional β
cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that …

Beta cells adapt their function to respond to fluctuating glucose concentrations and variable
insulin demand. The highly specialized beta cells have well-established endoplasmic …

Milk, the secretory product of the lactation genome, promotes growth of the newborn
mammal. Milk delivers insulinotropic amino acids, thus maintains a molecular crosstalk with …