Hepatitis C virus vaccine design: focus on the humoral immune response
D Sepulveda-Crespo, S Resino, I Martinez - Journal of Biomedical Science, 2020 - Springer
Despite the recent development of safe and highly effective direct-acting antivirals, hepatitis
C virus (HCV) infection remains a significant health problem. In 2016, the World Health …
C virus (HCV) infection remains a significant health problem. In 2016, the World Health …
Exploiting B cell receptor analyses to inform on HIV-1 vaccination strategies
The human antibody repertoire is generated by the recombination of different gene
segments as well as by processes of somatic mutation. Together these mechanisms result in …
segments as well as by processes of somatic mutation. Together these mechanisms result in …
Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C
A Nishio, S Hasan, H Park, N Park, JH Salas… - Nature …, 2022 - nature.com
The increasing incidence of hepatitis C virus (HCV) infections underscores the need for an
effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting …
effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting …
Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion
E Salinas, M Boisvert, AA Upadhyay… - The Journal of …, 2021 - Am Soc Clin Investig
Early appearance of neutralizing antibodies during acute hepatitis C virus (HCV) infection is
associated with spontaneous viral clearance. However, the longitudinal changes in antigen …
associated with spontaneous viral clearance. However, the longitudinal changes in antigen …
Convergent antibody responses are associated with broad neutralization of hepatitis C virus
Introduction Early development of broadly neutralizing antibodies (bNAbs) targeting the
hepatitis C virus (HCV) envelope glycoprotein E2 is associated with spontaneous clearance …
hepatitis C virus (HCV) envelope glycoprotein E2 is associated with spontaneous clearance …
Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein
The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet
described, and are the current focus of immunogen design in HCV vaccine development; …
described, and are the current focus of immunogen design in HCV vaccine development; …
Hepatitis C virus epitope immunodominance and B cell repertoire diversity
Despite the advent of effective, curative treatments for hepatitis C virus (HCV), a preventative
vaccine remains essential for the global elimination of HCV. It is now clear that the induction …
vaccine remains essential for the global elimination of HCV. It is now clear that the induction …
Characterization of linear epitope specificity of antibodies potentially contributing to spontaneous clearance of hepatitis C virus
Background Around 30% of the HCV infected patients can spontaneously clear the virus.
Cumulative evidence suggests the role of neutralizing antibodies in such spontaneous …
Cumulative evidence suggests the role of neutralizing antibodies in such spontaneous …
Substitution of the CD81 Binding Site and β-Sandwich Area in E2 of HCV in Cambodia
C Yamamoto, S Nagashima, C Chuon, K Ko, S Huy Do… - Viruses, 2020 - mdpi.com
The high genetic variability of hepatitis C virus (HCV) is the main obstacle to developing a
vaccine. E2 has attracted attention for vaccine development because targeting this protein …
vaccine. E2 has attracted attention for vaccine development because targeting this protein …
Association of the sialylation of antibodies specific to the HCV E2 envelope glycoprotein with hepatic fibrosis progression and antiviral therapy efficacy
O Kurtenkov, J Jakovleva, B Sergejev… - Disease …, 2020 - Wiley Online Library
The E2 envelope glycoprotein of the hepatitis C virus (HCV) is a major target of broadly
neutralizing antibodies that are closely related to a spontaneous cure of HCV infection …
neutralizing antibodies that are closely related to a spontaneous cure of HCV infection …