Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …

Radiation-induced lung injury (RILI) is one of the main dose-limiting toxicities in radiation
therapy (RT) for lung cancer. Approximately 10% to 20% of patients show signs of RILI of …

Background Approximately half of adults with chronic obstructive pulmonary disease
(COPD) remain undiagnosed. Chest CT scans are frequently acquired in clinical practice …

Dysanapsis refers to an anthropometric mismatch of airway tree calibre that was first inferred
from inter-individual differences in maximum expiratory airflow among healthy adults [2] and …

Dysanapsis, a mismatch between airway tree caliber and lung size, contributes to a large
variation in lung function on spirometry in healthy subjects. However, it remains unclear …

CT scan imaging provides high-resolution images of the lungs in patients with chronic
respiratory diseases. Extensive research over the last several decades has focused on …

Rationale: Emphysema progression is heterogeneous. Predicting temporal changes in lung
density and detecting rapid progressors may facilitate the selection of individuals for …

Backgrounds The respiratory microbiota and radiomics correlate with the disease severity
and prognosis of chronic obstructive pulmonary disease (COPD). We aim to characterize the …

Asthma is a common disorder affecting around 315 million individuals worldwide. The
heterogeneity of asthma is becoming increasingly important in the era of personalized …

Background Airflow reversibility criteria in COPD are still debated–especially in situations of
co-existing COPD and asthma. Bronchodilator response (BDR) is usually assessed by …