Integrase and integration: biochemical activities of HIV-1 integrase
Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
Resistance to integrase inhibitors
M Métifiot, C Marchand, K Maddali, Y Pommier - Viruses, 2010 - mdpi.com
Integrase (IN) is a clinically validated target for the treatment of human immunodeficiency
virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced …
virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced …
Structure-based modeling of the functional HIV-1 intasome and its inhibition
L Krishnan, X Li, HL Naraharisetty… - Proceedings of the …, 2010 - National Acad Sciences
The intasome is the basic recombination unit of retroviral integration, comprising the
integrase protein and the ends of the viral DNA made by reverse transcription. Clinical …
integrase protein and the ends of the viral DNA made by reverse transcription. Clinical …
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
E Guiot, K Carayon, O Delelis, F Simon, P Tauc… - Journal of Biological …, 2006 - ASBMB
The 3′-processing of the extremities of viral DNA is the first of two reactions catalyzed by
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics
F DeAnda, KE Hightower, RT Nolte, K Hattori… - PLoS …, 2013 - journals.plos.org
Signature HIV-1 integrase mutations associated with clinical raltegravir resistance involve 1
of 3 primary genetic pathways, Y143C/R, Q148H/K/R and N155H, the latter 2 of which confer …
of 3 primary genetic pathways, Y143C/R, Q148H/K/R and N155H, the latter 2 of which confer …
HIV‐1 integrase inhibitors: 2005–2006 update
Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome,
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …
Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor
F Michel, C Crucifix, F Granger, S Eiler… - The EMBO …, 2009 - embopress.org
Integration of the human immunodeficiency virus (HIV‐1) cDNA into the human genome is
catalysed by integrase. Several studies have shown the importance of the interaction of …
catalysed by integrase. Several studies have shown the importance of the interaction of …
Resistance to HIV-1 integrase inhibitors: a structural perspective
Strand-transfer inhibitors, of which raltegravir, elvitegravir and S/GSK1349572, is a new
class of antiretrovirals that inhibit HIV integrase-catalyzed insertion of the HIV-1 genome into …
class of antiretrovirals that inhibit HIV integrase-catalyzed insertion of the HIV-1 genome into …
Impact of Y143 HIV-1 Integrase Mutations on Resistance to Raltegravir In Vitro and In Vivo
ABSTRACT Integrase (IN), the HIV-1 enzyme responsible for the integration of the viral
genome into the chromosomes of infected cells, is the target of the recently approved …
genome into the chromosomes of infected cells, is the target of the recently approved …
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes
Oxidative protein folding in Gram-negative bacteria results in the formation of disulfide
bonds between pairs of cysteine residues. This is a multistep process in which the dithiol …
bonds between pairs of cysteine residues. This is a multistep process in which the dithiol …