Development and deployment of COVID-19 vaccines for those most vulnerable

WC Koff, T Schenkelberg, T Williams… - Science translational …, 2021 - science.org
Development of safe and effective COVID-19 vaccines is a global priority and the best hope
for ending the COVID-19 pandemic. Remarkably, in less than 1 year, vaccines have been …

Animal models for influenza virus pathogenesis, transmission, and immunology

RR Thangavel, NM Bouvier - Journal of immunological methods, 2014 - Elsevier
In humans, infection with an influenza A or B virus manifests typically as an acute and self-
limited upper respiratory tract illness characterized by fever, cough, sore throat, and malaise …

Recent advances in CD8+ regulatory T cell research

Y Yu, X Ma, R Gong, J Zhu, L Wei… - Oncology …, 2018 - spandidos-publications.com
Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but
also serve important regulatory roles in the body's immune response. In particular, CD8+ …

Back to the future for influenza preimmunity—Looking back at influenza virus history to infer the outcome of future infections

ME Francis, ML King, AA Kelvin - Viruses, 2019 - mdpi.com
The influenza virus-host interaction is a classic arms race. The recurrent and evolving nature
of the influenza virus family allows a single host to be infected several times. Locked in co …

Treating influenza with statins and other immunomodulatory agents

DS Fedson - Antiviral Research, 2013 - Elsevier
Statins not only reduce levels of LDL-cholesterol, they counteract the inflammatory changes
associated with acute coronary syndrome and improve survival. Similarly, in patients …

Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies

CP Arevalo, V Le Sage, MJ Bolton… - Proceedings of the …, 2020 - National Acad Sciences
Immunity to influenza viruses can be long-lived, but reinfections with antigenically distinct
viral strains and subtypes are common. Reinfections can boost antibody responses against …

After the virus has cleared—Can preclinical models be employed for Long COVID research?

EB Jansen, SN Orvold, CL Swan, A Yourkowski… - PLoS …, 2022 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can cause the life-
threatening acute respiratory disease called COVID-19 (Coronavirus Disease 2019) as well …

Complexities in ferret influenza virus pathogenesis and transmission models

JA Belser, AM Eckert, TM Tumpey… - … and Molecular Biology …, 2016 - Am Soc Microbiol
Ferrets are widely employed to study the pathogenicity, transmissibility, and tropism of
influenza viruses. However, inherent variations in inoculation methods, sampling schemes …

Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multicentre cohort study

H Luo, S Liu, Y Wang, PA Phillips-Howard, S Ju… - BMJ open, 2020 - bmjopen.bmj.com
Objectives To determine the age-specific clinical presentations and incidence of adverse
outcomes among patients with COVID-19 in Jiangsu, China. Design and setting …

Animal models for influenza viruses: implications for universal vaccine development

I Margine, F Krammer - Pathogens, 2014 - mdpi.com
Influenza virus infections are a significant cause of morbidity and mortality in the human
population. Depending on the virulence of the influenza virus strain, as well as the …