Serotonin, also known as 5-hydroxytryptamine (5-HT) is a signaling mediator that regulates
emotion, behavior, and cognition. Previous studies have focused more on the roles of 5-HT …

Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Sepsis is a dysregulation of the immune response to pathogens and has high morbidity and
mortality worldwide. However, the unclear mapping and course of dysregulated immune …

Abstract Background Systemic sclerosis (SSc) is a chronic and systemic autoimmune
disease marked by the skin and visceral fibrosis. Metabolic alterations have been found in …

Systemic sclerosis (SSc) is an autoimmune, inflammatory and fibrotic disease with limited
treatment options. Developing new therapies is therefore crucial to address patient needs …

Background To explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and
hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and underlying molecular …

Background Polycystic ovary syndrome (PCOS) is a lifelong metabolic disorder and the most
common cause of anovulatory infertility affecting women in reproductive age. Our recent …

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune
dysregulation, and multi-organ fibrosis. Interstitial lung disease (ILD) is a complication of …

We provide an original multi-stage approach identifying a gene signature to assess murine
fibroblast polarization. Prototypic polarizations (inflammatory/fibrotic) were induced by …