Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in
molecular biology. There are now over 2000 miRNAs that have been discovered in humans …

Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …

Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …

Abstract microRNAs (miRNAs) are important modulators of development. Owing to their
ability to simultaneously silence hundreds of target genes, they have key roles in large-scale …

Skeletal muscle is the dominant organ system in locomotion and energy metabolism.
Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas …

According to the current view, each microRNA regulates hundreds of genes. Computational
tools aim at identifying microRNA targets, usually selecting evolutionarily conserved …

Muscle specific miRNAs, myomiRs, have been shown to control muscle development in vitro
and are differentially expressed at rest in diabetic skeletal muscle. Therefore, we …

The Pax7 transcription factor is required for muscle satellite cell biogenesis and specification
of the myogenic precursor lineage. Pax7 is expressed in proliferating myoblasts but is …

Rationale: MicroRNA (miR)-1 and-133 play a crucial role in skeletal and cardiac muscle
biology and pathophysiology. However, their expression and regulation in vascular cell …