Inflammaging and osteoarthritis

F Motta, E Barone, A Sica, C Selmi - Clinical Reviews in Allergy & …, 2023 - Springer
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

[PDF][PDF] The genesis of pain in osteoarthritis: inflammation as a mediator of osteoarthritis pain

MJ Wood, RE Miller, AM Malfait - Clinics in geriatric medicine, 2022 - Elsevier
Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

CD Verrico, S Wesson, V Konduri, CJ Hofferek… - Pain, 2020 - journals.lww.com
1. Background Arthritis is a leading cause of pain, disfigurement, and disability in the United
States where nearly one-quarter of all adults have received an affirmative diagnosis. 2 …

Monocytes, macrophages, and their potential niches in synovial joints–therapeutic targets in post-traumatic osteoarthritis?

P Haubruck, MM Pinto, B Moradi, CB Little… - Frontiers in …, 2021 - frontiersin.org
Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

[HTML][HTML] Recent advances in understanding the phenotypes of osteoarthritis

A Mobasheri, S Saarakkala, M Finnilä… - …, 2019 - ncbi.nlm.nih.gov
Recent research in the field of osteoarthritis (OA) has focused on understanding the
underlying molecular and clinical phenotypes of the disease. This narrative review article …

The potential role of synovial cells in the progression and treatment of osteoarthritis

Z Zou, H Li, K Yu, K Ma, Q Wang, J Tang, G Liu… - …, 2023 - Wiley Online Library
Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …

Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis

M Rahimi, G Charmi, K Matyjaszewski, X Banquy… - Acta biomaterialia, 2021 - Elsevier
Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in
older populations and is expected to be the most dominant cause of disability in the world …

Matrix metalloproteinase 3: a promoting and destabilizing factor in the pathogenesis of disease and cell differentiation

J Wan, G Zhang, X Li, X Qiu, J Ouyang, J Dai… - Frontiers in …, 2021 - frontiersin.org
Cells must alter their expression profiles and morphological characteristics but also reshape
the extracellular matrix (ECM) to fulfill their functions throughout their lifespan. Matrix …

CC chemokines and receptors in osteoarthritis: new insights and potential targets

Y Zhang, D Liu, DTA Vithran, BR Kwabena… - Arthritis Research & …, 2023 - Springer
Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of
innate and adaptive immune systems-associated inflammatory responses. Due to the local …

The involvement of neutrophils in the pathophysiology and treatment of osteoarthritis

S Chaney, R Vergara, Z Qiryaqoz, K Suggs, A Akkouch - Biomedicines, 2022 - mdpi.com
Osteoarthritis (OA) is a chronic disability that significantly impairs quality of life. OA is one of
the most prevalent joint pathologies in the world, characterized by joint pain and stiffness …