Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …

Interferon (IFN) signaling induces the expression of a wide array of genes, collectively
referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication …

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …

Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …

Abstract RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process
that is crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation …

An important property of the host innate immune response during microbial infection is its
ability to control the expression of antimicrobial effector proteins, but how this occurs post …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

During viral infection, virus-derived cytosolic nucleic acids are recognized by host
intracellular specific sensors. The efficacy of this recognition system is crucial for triggering …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …