Cancer cells commonly exhibit various forms of genetic instability, such as changes in
chromosome copy number, translocations and point mutations in particular genes. Although …

Background Gene rearrangements such as chromosomal translocations have been shown
to contribute to cancer development. Human chromosomal fragile sites are regions of the …

Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks
on metaphase chromosomes following conditions of partial replication stress. Fragile sites …

Chromosome fragile sites are a fascinating cytogenetic phenomenon now widely implicated
in a slew of human diseases ranging from neurological disorders to cancer. Yet, the paths …

Neither the molecular basis for common fragile site DNA instability nor the contribution of
this form of chromosomal instability to cancer is clearly understood. Fragile site FRA16D …

Background This study analyzed multiple parameters including somatic single nucleotide
variations (SNVs), Insertion/Deletions, significantly mutated genes (SMGs), copy number …

The common fragile site FRA6F, located at 6q21, is an extended region of about 1200 kb,
with two hot spots of breakage each spanning about 200 kb. Transcription mapping of the …

Organophosphate-based pesticides have been associated with pathology and
chromosomal damage in humans. There are also epidemiologic links with cancer. The few …

Fragile sites are specific regions of chromosomes prone to breakage when cells are cultured
under specific conditions. These sites are divided into two classes: common and rare …

The incidence of thyroid cancer is increasing, especially papillary thyroid carcinoma (PTC),
making it currently the fastest‐growing cancer among women. Reasons for this increase …