Developing reliable, predictive animal models for complex psychiatric disorders, such as
schizophrenia, is essential to increase our understanding of the neurobiological basis of the …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

Since the first description of their opioid properties three decades ago, dynorphins have
increasingly been thought to play a regulatory role in numerous functional pathways of the …

The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered.
Several animal models use knockout (KO) mice that display schizophrenia-like behaviors …

Dopamine D 2 receptor antagonism is a unifying property of all antipsychotic drugs in use for
schizophrenia. While often effective at ameliorating psychosis, these drugs are largely …

Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …

We propose that postmortem tissue is an underutilized substrate that may be used to
translate genetic and/or preclinical studies, particularly for neuropsychiatric illnesses with …

Background: Schizophrenia is a serious mental illness that affects more than 21 million
people worldwide. Both genetics and the environment play a role in its etiology and …

Toxoplasma gondii is not only implicated in schizophrenia and related disorders, but also in
Alzheimer′ s or Parkinson′ s disease, cancer, cardiac myopathies, and autoimmune …

Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an
essential step in the rational development of new antipsychotic drugs for this devastating …